FsQtlMap 1.0

A Windows Software for Mapping QTL in a Full-sib Family

Chunfa Tong (Email: tongchf@njfu.edu.cn)

Key Laboratory of Genetics & Biotechnology (Nanjing Forestry University), Ministry of Education, China

FsQtlMap is a Windows software for mapping QTL with molecular markers and trait values in a full-sib family, which can be derived by hybridizing two outbred parents. The software is written in VC++ 6.0 and works with Microsoft Windows operating systems, including Windows 95/98, Me, NT, 2000, and XP.

FsQtlMap is based on interval mapping method and assumes that the segregation pattern in a potential quantitative trait locus (QTL) can be divided into three types, testcross (segregating 1:1), F2 cross (segregating 1:2:1), and full cross (segregating 1:1:1:1) in a full-sib family. FsQtlMap uses Laplace-emprical criterion (LEC) as a model selection criterion to discriminate the QTL segregation ratio, and the free software, gnuplot , to plot LOD profiles along the linkage groups. In practical QTL mapping, the genome-wide LOD threshold for asserting a peak of the profile to be a QTL can be obtained through permutations for each of the three QTL models.

The software and its manual can be freely downloaded from the following links.

+ FsQtlMap 1.0
+ Manual

Chunfa Tong, Bo Zhang, Huogen Li, and Jisen Shi. 2012. Model selection for quantitative trait loci mapping in a full-sib family. Genetics and Molecular Biology, 35(3):