A Windows Software for Mapping QTL in a Full-sib Family
Chunfa Tong (Email: firstname.lastname@example.org)
Key Laboratory of Genetics & Biotechnology (Nanjing Forestry University), Ministry of Education, China
FsQtlMap is a Windows software for mapping QTL with molecular markers and trait values in a full-sib family, which can be derived by hybridizing two outbred parents. The software is written in VC++ 6.0 and works with Microsoft Windows operating systems, including Windows 95/98, Me, NT, 2000, and XP.
FsQtlMap is based on interval mapping method and assumes that the segregation pattern in a potential quantitative trait locus (QTL) can be divided into three types, testcross (segregating 1:1), F2 cross (segregating 1:2:1), and full cross (segregating 1:1:1:1) in a full-sib family. FsQtlMap uses Laplace-emprical criterion (LEC) as a model selection criterion to discriminate the QTL segregation ratio, and the free software, gnuplot , to plot LOD profiles along the linkage groups. In practical QTL mapping, the genome-wide LOD threshold for asserting a peak of the profile to be a QTL can be obtained through permutations for each of the three QTL models.
The software and its manual can be freely downloaded from the following links.